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T22089 |
HPI 1
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Hedgehog/Smoothened
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HPI 1 is a hedgehog (Hh) signaling inhibitor. Inhibits Sonic hedgehog (Shh)-, SAG- and Gli-induced Hh pathway activation in Shh-LIGHT2 cells (IC50 values are 1.5, 1.5, 4, and 6 μM for Shh-, SAG-, Gli2- and Gli1-induced a... |
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T10723 |
CDC25B-IN-1
|
ethyl 3-[(3-methoxynaphthalen-1-yl)amino]benzoate |
Phosphatase
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CDC25B-IN-1 is an inhibitor of CDC25B with a Ki of 8.5 μM. CDC25B-IN-1 increases the G2/M phase by inhibiting cell proliferation and colony formation. |
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T2011 |
RKI1313
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RKI 1313,RKI-1313 |
ROCK
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RKI1313 (RKI-1313) was a selective inhibitor for ROCK-dependent signaling, cytoskeletal changes, anchorage-independent colony formation, migration, and invasion. |
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T61722 |
ZDLD20
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Apoptosis
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ZDLD20 is an orally active and selective CDK4 inhibitor, a β-carboline analog with anti-HCT116 and anticancer activity that inhibits colony formation, inhibits invasion and migration, induces apoptosis, and prevents the ... |
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T60197 |
UNC 1025
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Others
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UNC1062 is a highly selective tyrosine kinase inhibitor that specifically targets MERTK. This compound effectively suppresses MERTK-mediated downstream signaling, induces apoptosis in cell cultures, reduces colony format... |
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T37518 |
Diphenyl disulfide
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Phenyl disulfide |
Apoptosis
,
BCL
,
Endogenous Metabolite
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Diphenyl disulfide (Phenyl disulfide) shows anticancer activity in breast cancer cell lines.Diphenyl disulfide induces and enhances apoptosis in breast cancer cells through Bax protein hydrolysis activation and concomita... |
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T77677 |
12R-LOX-IN-2
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Lipoxygenase
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12R-LOX-IN-2 is an inhibitor of 12R-lipoxygenase (12R-LOX).12R-LOX-IN-2 inhibits imiquimod (IMQ)-induced hyperproliferation of psoriatic keratinocytes and inhibits colony formation.12R-LOX-IN-2 also decreases the protein... |
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T23726 |
WB-308
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WB308 |
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WB-308 is an EGFR inhibitor that acts by decreasing NSCLC cell proliferation and colony formation and causing G2/M arrest and apoptosis. |
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T28848 |
SR31527
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SR-31527,SR31527 chloride,SR 31527 |
Kinesin
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SR31527 (SR31527 chloride) is a potent KIFC1 inhibitor with an IC50 of 6.6 µM against KIFC1. SR31527 chloride has a moderate inhibitory effect on cell viability and colony formation. |
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T11691 |
IV-23
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Others
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IV-23, a potent inhibitor of cell growth both in vitro and in vivo, effectively reduces colony formation, arrests the cell cycle at the M phase, and induces apoptosis in esophageal squamous cell carcinoma through Noxa-me... |
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T24411 |
Y08060
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Y 08060,Y-08060 |
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Y08060 is an effective and selective BET Inhibitor for the Treatment of Prostate Cancer. Y08060 effectively suppresses cell growth, colony formation, and expression of androgen receptor (AR), AR regulated genes, and MYC ... |
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T79289 |
Antiproliferative agent-27
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Apoptosis
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Antiproliferative Agent-27 (Compound 11) is a notable antiproliferative agent that markedly diminishes tumor cell colony formation and induces apoptosis, demonstrating potential for utilization in cancer research [1]. |
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T60672 |
GSD-11
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GSD-11 inhibits the Akt/mTOR signaling pathway. GSD-11 inhibits the PANC-1 cells migration and colony formation. GSD-11 is a potent and selective anti-austerity agent that has the potential for the pancreatic cancer rese... |
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T69205 |
GGTI-2166
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GGTI-2166 is a geranylgeranyl transferase I inhibitor. GGTI-2166 inhibit the pOC formation induced by RANKL or TNF-alpha in cultures of both mouse marrow-derived macrophage-colony-stimulating factor (M-CSF) dependent mo... |
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T62398 |
KH-3
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KH-3 is a potent inhibitor (IC50: 0.35 μM) of the RNA-binding protein Hu antigen R (HuR) and exhibits anti-proliferative effects. KH-3 interferes with HuR-FOXQ1 Mrna interactions, inhibits breast cancer cell invasion, an... |
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T74919 |
QA-68
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QA-68 (QA-68-ZU81), a potent bromodomain-containing protein 9 (BRD9) degrader, effectively inhibits cell cycle progression and cell colony formation. Demonstrating antiproliferative activity, this compound is particularl... |
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T78768 |
HDAC6-IN-16
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HDAC
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HDAC6-IN-16 (compound 5c), a quinazolin-4(3H)-one-based inhibitor of histone deacetylase 6 (HDAC6), demonstrates an anticancer effect by inhibiting colony formation, arresting the cell cycle at the G2 phase, and inducing... |
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T79434 |
Antitumor agent-103
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Apoptosis
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Antitumor Agent-103 (compound 24l) induces apoptosis and possesses antiproliferative and anti-colony formation properties. This compound halts the cell cycle at the G0/G1 phase, augments nitric oxide (NO) production, and... |
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T74542 |
YM458
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Histone Methyltransferase
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YM458, a potent dual inhibitor of EZH2 and BRD4, exhibits IC50 values of 490 nM and 34 nM, respectively. This compound effectively hinders cell proliferation and colony formation, while also inducing cell cycle arrest an... |
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T78746 |
Mtb-IN-3
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Mtb-IN-3 (compound 10c), a selective and potent Mycobacterium tuberculosis (Mtb) inhibitor, exhibits strong antimycobacterial activity in vitro without inducing cytotoxic effects and inhibits colony formation in the sple... |
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T79445 |
KV1.3-IN-1
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Potassium Channel
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KV1.3-IN-1 (Compound trans-18), a selective KV1.3 channel inhibitor with IC50 values of 230 nM in Ltk cells and 26.12 nM in PHA-activated T-lymphocytes, disrupts intracellular Ca2+ signaling and impedes T-cell activation... |
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T78837 |
CP-07
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CDK
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CP-07 is a selective and effective PROTAC CDK9 degrader (DC50: 43 nM), demonstrating inhibition of 22RV1 cell proliferation (IC50: 62 nM) and colony formation by attenuating levels of Mcl-1 and c-Myc. Additionally, CP-07... |
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T28269 |
ORY-1001 free base
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RG 6016,ORY-1001,ORY 1001,ORY1001,RG-6016,RG6016 |
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ORY-1001 is a KDM1A inhibitor (IC50 <20nM) with high selectivity against related FAD dependent aminoxidases (MAO-A/B, IL4I1, KDM1B >100uM, SMOX 7uM). Treatment of THP-1 (MLL-AF9) cells with ORY-1001, results in a time/do... |
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T64210 |
ATX inhibitor 13
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ATX inhibitor 13 (compound 10c) is an orally active ATX inhibitor (IC50: 3.4 nM). ATX inhibitor 13 is capable of blocking the cell cycle of RAW264.7 cells in the G2 phase, inhibiting cell proliferation and migration and ... |
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T64014 |
Antitumor agent-58
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Antitumor agent-58 is an antitumour agent that effectively inhibits colony formation and cell migration in MGC-803 cells and induces mitochondrial dysfunction in MGC-803 cells. Antitumor agent-58 exhibited potent inhibit... |
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T60689 |
ZDLD13
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ZDLD13 is a β-carboline that exhibits potent anti-HCT116 activity inclusive of inhibition of invasion and migration, inhibition of colony formation, inducing of apoptosis as well as arresting of G1 phase in cell cycle. Z... |
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T83023 |
Antiproliferative agent-26
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Antiproliferative agent-26 (compound 4g) exhibits a broad spectrum of activity against leukemia, CNS cancers, melanoma, renal, and breast cancers at a concentration of 10 μM. It hinders colony formation and induces cell ... |
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T78880 |
Tubulin/HDAC-IN-3
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Tubulin/HDAC-IN-3 (compound 12a) serves as a potent dual inhibitor of tubulin polymerization and HDAC1/8, exhibiting IC50 values of 5.4 μM for tubulin polymerization, and 0.155 and 0.177 μM for HDAC1 and HDAC8, respectiv... |
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T36514 |
QD-394
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QD-394 is an inducer of reactive oxygen species (ROS) production.1It induces lipid peroxidation, increases in intracellular accumulation of reactive oxygen species (ROS), and decreases in the reduced glutathione (GSH) to... |
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T64027 |
ALK-IN-23
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ALK-IN-23 is a potent inhibitor of ALK, acting on ALKWT (IC50: 1.6 nM), ALKL1196M (IC50: 0.71 nM) and ALKG1202R (IC50: 1.3 nM). -IN-23 has inhibitory effects on cancer cell migration and colony formation in vitro. In the... |
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T63590 |
C-Met-IN-10
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c-Met-IN-10 is a potent c-Met kinase inhibitor (IC50: 16 nM). c-Met-IN-10 inhibits the activity of cancer cells A549, H460 and HT-29, and inhibits A549 cell movement by inhibiting HT-29 cell colony formation, which in tu... |
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T37050 |
MPS1/TTK Inhibitor
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MPS1/TTK Inhibitor |
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MPS1/TTK inhibitor is an inhibitor of monopolar spindle 1 (MPS1/TTK; IC50 = 5.8 nM), a kinase involved in mitotic spindle checkpoint signaling that is overexpressed in certain cancerous tumors. It inhibits MPS1 phosphory... |
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T79685 |
PI3Kα-IN-13
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PI3K
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PI3Kα-IN-13 (Compound 18a), a PI3Kα inhibitor with an IC50 of 2.5 nM, effectively induces apoptosis and hampers the proliferation of various cancer cell lines, exhibiting IC50 values of 0.75 μM (MCF-7), 3.79 μM (HCT-116)... |
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T69682 |
AEW541 HCl
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AEW541, also known as NVP-AEW541, is a novel, potent IGF-IR kinase inhibitor. NVP-AEW541 is capable of distinguishing between the IGF-IR (IC50 = 0.086 microM) and the closely related InsR (IC50 = 2.3 microM) in cells. NV... |
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T37873 |
CAP 3
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CAP 3 is a cholic acid-peptide conjugate (CAP) with antibacterial activity. It is active against the Gram-negative bacteria E. coli, K. pneumoniae, and A. baumanii (MIC99s = 8, 16, and 16 μM, respectively). CAP 3 increas... |
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T83914 |
Glutaminase C Inhibitor 11
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Glutaminase C Inhibitor 11 is a potent inhibitor specifically targeting Glutaminase C (GAC), demonstrating significant inhibition of GAC enzyme activity with an EC50 value of 10.64 nM. It effectively diminishes the viabi... |
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T78853 |
PI3K-IN-47
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PI3K
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PI3K-IN-47 (Compound 27) is a potent bivalent inhibitor targeting the phosphoinositide 3-kinases (PI3K) family, exhibiting inhibitory concentration (IC50) values of 0.44 nM for PI3Kα, and 7.18 nM, 13.92 nM, 22.83 nM for ... |
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T3512 |
S49076 HCl
|
S-49076 Hydrochloride |
FGFR
,
c-Met/HGFR
,
TAM Receptor
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S49076 HCl (S-49076 Hydrochloride) is an effective inhibitor of MET, AXL/MER, and FGFR1/2/3. S49076 HCl potently blocked cellular phosphorylation of MET, AXL, and FGFRs and inhibited downstream signaling in vitro and in ... |
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T35955 |
PAR2 (1-6) amide (human) (trifluoroacetate salt)
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PAR2 (1-6) amide (human) (trifluoroacetate salt) |
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PAR2 (1-6) amide is a synthetic peptide agonist of proteinase-activated receptor 2 (PAR2) that corresponds to residues 1-6 of the amino terminal tethered ligand sequence of human PAR2 and residues 37-42 of the full-lengt... |
